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It's very simple for me. I add work friends (TLs included but I don't add them if they add me it's okay I'll accept) and put them on their own list. So all the people I work with are in this work list...so, if I write a status talking about how I hate my job or something, I can edit the privacy settings so all my friends can see it (except the list, "work"). Since it's friends only with that exception, the public can't see it either, so no worries about Spot trying to search for me post if I mention Target.
I have a few what I like to call "Target Loyalists" on a certain facebook list of mine as well. They're people I get along with well, just don't want them reading what I post about spot. I removed all the TLs off my facebook, I don't really trust any of them.